Detection of cytotoxic effects of Clostridium novyi type a on bovine kidney cells

Kanoe, M.; Masui, Y.; Murakami, Y.; Yaguchi, Y.

Microbios 95(380): 7-13

1998


ISSN/ISBN: 0026-2633
PMID: 9881459
Document Number: 486830
The cytotoxic effects of a toxic preparation from Clostridium novyi type A were demonstrated on tissue-cultured bovine kidney cells. The cytotoxic response was dose-dependent and could be neutralized by homologous antiserum. Scanning electron microscopy revealed damaged kidney cell surfaces. These findings indicated that the cytotoxicity may contribute to the formation of the foci in bovine tissue during an infection with C. novyi.

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