Vaginal absorption of low-dose tranexamic acid from impregnated tampons
Moodley, J.; Cohen, M.; Devraj, K.; Dutton, M.
South African Medical Journal 81(3): 150-152
1992
ISSN/ISBN: 0256-9574 PMID: 1734554 Document Number: 4867
Tranexamic acid (TA), an antifibrinolytic drug, is usually administered orally to women with menorrhagia. This route of administration is associated with adverse side-effects, therefore tampons impregnated with TA were used to assess the absorption of the drug across the vaginal epithelium. Blood levels of TA in group A (9 patients), who had one tampon inserted, and group B (10 patients), who had a tampon inserted at 2-hourly intervals so that a total of 3 tampons were administered over a 6-hour period, demonstrated absorption of the drug into the blood stream in low concentrations.
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