Myelodysplastic syndrome in a child with a history of medulloblastoma
Akyüz, C.; Emir, S.; Güler, N.; Tüker, A.; Büyükpamukçu, M.
Turkish Journal of Pediatrics 40(1): 131-134
1998
ISSN/ISBN: 0041-4301 PMID: 9673540 Document Number: 486441
We present a case of myelodysplastic syndrome (MDS) following treatment for medulloblastoms. The tumor was diagnosed at 15 years of age and managed with surgery, craniospinal radiation and a triple-durg regimen (chloroethylnitrosourea (CCNU), vincristine (VCR), procarbazine). Fifteen months after the completion of therapy, the patient developed MDS with monosomy 5 and monosomy 7 on chromosome analysis of bone marrow cells. Two weeks later, MDS evolved into acute myeloblastic leukemia (AML). Therapy-related MDS or AML may be a complication for patients with past brain tumors. Therefore, they should be carefully followed up by regular physical examinations and complete blood counts.