A patient with Tn syndrome associated with myelodysplastic syndrome showed abnormal glycophorin B
Kamesaki, T.; Akifuji, Y.; Mori, M.; Ueki, J.; Nakamoto, S.; Kajii, E.; Ikemoto, S.
International Journal of Hematology 58(1-2): 113-118
1993
ISSN/ISBN: 0925-5710 PMID: 8219107 Document Number: 405416
A Japanese male patient with myelodysplastic syndrome (MDS) was shown to have associated Tn syndrome; the first report of Tn syndrome with MDS. The Tn expression was demonstrated on erythrocytes, granulocytes, monocytes, platelets, and lymphocytes by flow cytometric analysis using a lectin and an antibody. Electrophoresis of erythrocyte membrane proteins revealed slower mobility of glycophorin B from the patient than that from normal individuals, suggesting a glycophorin B molecular abnormality.