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Telomerase activity in esophageal carcinoma and lesions unstained with Lugol's solution

Yoneyama, K.; Aoyama, N.; Koizumi, H.; Tamai, S.

Nihon Rinsho. Japanese Journal of Clinical Medicine 56(5): 1181-1185

1998

ISSN/ISBN: 0047-1852
PMID: 9613118
Document Number: 486032
Telomerase is a specific enzyme required for the replication of telomeres. Its activity is detected in almost human cancers. We examined in esophageal carcinoma and lesions unstained with Lugol's solution telomerase activity by using telomeric repeat amplification protocol (TRAP) assay. Telomerase activity was detected in all 22 esophageal carcinomas, regardless of histopathological findings. In unstained lesions, telomerase activity was detected in 15 of 22; 10 squamous cell carcinomas, four dysplasia, one regenerative epithelium, no telomerase activity was found in seven; four normal esophageal epithelia, two Barrett's esophagi, one regenerative epithelium. These results suggest that telomerase activity may be a useful molecular marker for the diagnosis of esophageal carcinoma and of the early esophageal carcinoma in area unstained with Lugol's solution.

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