A case of primary splenic large cell lymphoma with a t (9;14) (p13;q32)
Kawakami, K.; Amakawa, R.; Miyanishi, S.; Okumura, A.; Hayashi, T.; Kurata, M.; Ohno, H.; Ohno, Y.; Fukuhara, S.
International Journal of Hematology 67(2): 191-198
1998
ISSN/ISBN: 0925-5710 PMID: 9631587 Document Number: 486008
t(9;14)(p13;q32), a subtype of 14q32 translocation, plays an essential role in the development of lymphoplasmacytoid lymphoma. t(9;14)(p13;q32) Causes juxtaposition of the PAX-5 gene on 9p13 and the IgH gene on 14q32, leading to the deregulation of the PAX-5 gene. We report a case of primary splenic lymphoma with a t(9;14). The histological diagnosis was diffuse large B-cell lymphoma without plasmacytoid differentiation. The lymphoma cells showed a complex karyotype including a t(9;14). Southern blot analysis localized the breakpoint of the PAX-5 gene within a couple of kb regions upstream of the exon 1A, although the involvement of the PAX-5 gene with the immunoglobulin heavy chain gene could not be confirmed.