Refractory hyperglycemia complicating an evolving connective tissue disease: response to cyclosporine
Kramer, N.; Rosenstein, E.D.; Schneider, G.
Journal of Rheumatology 25(4): 816-818
1998
ISSN/ISBN: 0315-162X PMID: 9558194 Document Number: 485998
A 33-year-old woman with longstanding rheumatoid arthritis and Sjögren's syndrome developed type B insulin resistance (diabetes mellitus due to anti-insulin receptor antibodies) simultaneous with the evolution of her rheumatic disease to mixed connective tissue disease. Cyclosporine therapy induced a remission of receptor antibody mediated insulin resistance and controlled clinical manifestations of her systemic lupus erythematosus and dermatomyositis, but had no effect on the sclerodermatous features of her illness.