Telomerase activity and telomere length as diagnostic tumor marker for ovarian tumors
Murakami, J.; Nagai, N.; Ohama, K.
Nihon Rinsho. Japanese Journal of Clinical Medicine 56(5): 1310-1315
1998
ISSN/ISBN: 0047-1852 PMID: 9613143 Document Number: 484482
Telomerase activity was detected in germ cells, stem cells and cancer cells. In tumors of the ovary, an organ that contains germ cells, the authors examined availability to detect telomerase activity. Telomerase activity of malignant tumors was extremely high compared with that of normal ovaries and benign tumors. Strength and frequency of telomerase activity in malignant tumors was significant different from that in benign tumors. Telomere length tended to be smaller for malignant tumors of advanced stage, but no significant relationship between telomere length and telomerase activity and tumor stage could be recognized. Telomerase activity may be a useful marker for the diagnosis of ovarian tumors.