Etiological analysis of thrombophilia
Tsuda, H.; Iida, H.; Nakahara, M.; Hattori, S.; Tanabe, S.; Fujise, M.; Kinoshita, S.; Hamasaki, N.
Rinsho Byori. Japanese Journal of Clinical Pathology 45(11): 1025-1030
1997
ISSN/ISBN: 0047-1860 PMID: 9396341 Document Number: 483899
We have established a system for etiological analysis of thrombophilia which includes assays of antithrombin III, protein C, protein S, plasminogen, fibrinogen, heparin cofactor II and lupus anticoagulants as well as gene analysis. The analysis conducted on 115 patients with venous thrombosis, arterial thrombosis and small vessel thrombosis revealed that forty-one patients(36% of the examined patients) were accompanied with decreased activities of protein S, protein C, antithrombin III and plasminogen. Eleven candidate causal mutations were found by gene analysis. These studies indicate that a comprehensive examination is instrumental in identifying and confirming the etiology in patients with thrombophilia.