Donor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping
Donovan, J.A.; Simmons, F.A.; Esrason, K.T.; Jamehdor, M.; Busuttil, R.W.; Novak, J.M.; Grody, W.W.
Transplantation 63(1): 80-84
1997
ISSN/ISBN: 0041-1337 PMID: 9000665 Document Number: 483354
Posttransplantation malignancy in the allograft is a rare complication of orthotopic liver transplantation. In the described case, an abnormal T-tube cholangiogram, performed 6 months after orthotopic liver transplantation between a male donor and a female recipient, prompted needle liver biopsy. A moderately differentiated adenocarcinoma was found. Fluorescence in situ hybridization for the Y chromosome indicated male origin of malignancy. Donor-related disease was confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. Results of these investigations qualified the recipient for a second liver transplant.