Pentavalent 99mTc DMSA: uptake into a variety of human rhabdomyosarcoma xenografts
Van der Wall, H.; Henderson, D.; Baker, R.; Murray, I.P.
In Vivo 11(1): 45-50
1997
ISSN/ISBN: 0258-851X PMID: 9067772 Document Number: 483267
Background. Rhabdomyosarcoma is a common soft tissue sarcoma of childhood. While Ga is currently the most accurate modality for imaging residual or recurrent tumour its dosimetry is unfavourable. Pentavalent 99mTc DMSA (99mTc (V) DMSA) has been shown to accumulate in this tumour in a limited number of clinical cases. Methods. Biodistribution of 99mTc (V) DMSA was determined in non-tumour bearing BALB-C mice. Operative specimens from four clinically 67Ga avid tumours were xenografted into nude mice and allowed to reach a significant size. Biodistribution studies were performed after the injection of 99mTc (V) DMSA in all animals and 125I HSA and 67Ga in a limited number of animals. Results. None of the tumours investigated demonstrated significant 99mTc (V) DMSA accumulation. Biodistribution was identical in tumour and non-tumour bearing animals. Conclusion. Rhabdomyosarcoma xenografts do not demonstrate significant uptake of 99mTc (V) DMSA.