A case of acute pyrimethamine poisoning
Aguemon, A.R.; Atchadé, D.; Houngbé, F.; Fayomi, B.
Bulletin de la Societe de Pathologie Exotique 90(2): 117-119
1997
ISSN/ISBN: 0037-9085 PMID: 9289249 Document Number: 482926
Intoxication by pyrimethamine is rare compare to these of patients who ingest a massive dose of amino-4-quinoleine. Clinic manifestations can be delayed and they are specially based on haematologic disorder as shown by literature data. Others organs can be concerned. The authors would like to present the case of a patient with a severe pancytopenia accompanied with: ocular blow like hyperhaemia of conjunctiva then iris siderosis. skin attack as Gũnther's disease. Etiologic treatment by folinic acid is the only deduction. Recovery is complete.