Cognitive sequelae of acute hydrogen sulphide poisoning. A case report
Fenga, C.; Cacciola, A.; Micali, E.
La Medicina del Lavoro 93(4): 322-328
2002
ISSN/ISBN: 0025-7818 PMID: 12212401 Document Number: 550799
Hydrogen Sulphide (H2S) is a highly toxic, colorless gas smelling of rotten eggs. It is used in several industries and is a product of many industrial processes such as oil refining, mining and rayon manufacture. Acute, non fatal H2S intoxication at a concentration of 500 ppm, for few minutes, is followed by brain damage characterised by both immediate and permanent neurobehavioural deficits. The present study describes the neurobehavioral effects of acute, non-fatal H2S intoxication in a healthy 36-year-old male at the workplace. Three months after the acute poisoning, the subject was examined via a neurological examination, neuropsychological tests (Mini Mental State, Verbal Span Test, Digit Span Test, Bourdon-Wiersma Dot Cancellation Test, Benton Visual Retention Test, Somatognosia, Simple Visual Reaction Time, Simple Acoustic Reaction Time), Nuclear Magnetic Resonance (NMR), and Single Photon Emission Tomography (SPET). The results showed a reduction of cognitive capabilities, depressive symptoms and personality changes even through the results of neurological examination and neuroimaging techniques were unremarkable. Neuropsychological testing is a key issue in neurotoxicology assessment, because conventional neurology has been shown to be insensitive to the chemical neurotoxic effects and neuroimaging techniques are often unclear.