Inhibition of microsomal glucose-6-phosphatase induced by ferrylmyoglobin
Miura, T.; Muraoka, S.; Ogiso, T.
Research Communications in Molecular Pathology and Pharmacology 96(3): 291-298
1997
ISSN/ISBN: 1078-0297 PMID: 9261888 Document Number: 482700
Ferrylmyoglobin (ferrylMb) caused inhibition of microsomal glucose-6-phosphatase (G6Pase) during membrane lipid peroxidation. Butylated hydroxytoluene prevented both the inactivation of G6Pase and the lipid peroxidation. Furthermore, ferrylMb was adsorbed on to the membranes and the membrane proteins polymerized during the lipid peroxidation, suggesting that the inactivation of microsomal G6Pase was due to the disturbance of the membrane structure induced by ferrylMb.