The preparation of poly (DL-lactide) hollow fiber and the release of drug in vitro
Zhu, J.; Shen, Z.; Ma, Z.; Wu, L.; Shi, D.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 14(3): 247-251
1997
ISSN/ISBN: 1001-5515 PMID: 11326842 Document Number: 482593
The biodegradable hollow fibers of DL-PLA were prepared by a dry-wet phase inversion spinning process. By using four different spinning systems, DL-PLA hollow fibers with varying asymmetric membrane structure were obtained. The structure of hollow fiber wall was examined by SEM. In vitro release of norethisterone from the DL-PLA hollow fibers was also investigated. The hollow fibers were filled with a 50 wt% NET in castor oil. The DL-PLA hollow fibers NET release was found to be dependent on the membrane structure of the hollow fiber wall. Possible release mechanisms were discussed.