Blood platelet adhesion molecules
Krejsek, J.; Loudová, M.; Kopecký, O.
Casopis Lekaru Ceskych 136(20): 624-626
1997
ISSN/ISBN: 0008-7335 PMID: 9490206 Document Number: 482529
Homeostasis is mediated through interactions of adhesion molecules on the surface of platelets which belong into the families of selectins, integrins and immunoglobulins with soluble plasma proteins, surface molecules of activated endothelial cells and molecules of extracellular matrix. The membrane expression of some adhesion molecules (P-selectin) which are the part of granular system of resting platelet identify activated platelet. Adhesion molecules of platelets could be detected by immunochemistry through flow cytometry. By this approach the inherited defects of adhesion molecules on platelets and the activated platelet could be detected. The detection of activated platelets is very useful in many clinical conditions.