eIF4G: a multipurpose ribosome adapter?
Hentze, M.W.
Science 275(5299): 500-501
1997
ISSN/ISBN: 0036-8075 PMID: 9019810 Document Number: 479839
To be joined as partners in protein synthesis, ribosomes and mRNAs must be presented to one another in the ritual of translation initiation. Recent data from several laboratories have indicated that a long-known translation initiation factor--eIF4G (formerly p220 or eIF-4c) is a crucial link between mRNAs and the small ribosomal 40S subunits during the initial engagement process. The writer discusses the translation initiation process in detail.