Molecular stereopharmacology and the search for stereoselective drugs
Sergeev, P.V.; Gatsura, V.V.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 11: 59-64
1997
ISSN/ISBN: 0869-6047 PMID: 9461827 Document Number: 479714
Analyzing modern trends in stereopharmacology shows that its theoretical aspects are mainly associated with the studies of the steric parameters of active centers of drug receptors and enzymes by using compounds having a well-established stereostructure. Applied stereopharmacology underlines the vital necessity of selective production and use of drug eutomers and active modifications of polymorphic drugs. The creation of an information computer database of stereostructural parameters of drugs is considered to be basic for further design of new selective drugs.