Experience with three minipills preparations with low dose progestagens for oral contraception
Richter, R.H.; Anhst-horridge, A.; Riemann-hunziker, R.; Roth, F.; Sprenger, S.; Turpeinen, K.
Schweizerische Zeitschrift für Gynakologie und Geburtshilfe. Revue Suisse de Gynecologie et d'Obstetrique 1(3-5): 218-220
1970
PMID: 12305610 Document Number: 479446
208 Swiss and Finnish women took the progestagen-only minipills megestrol acetate .5 mg, chlormadinone acetate .5 mg, or D-norgestrel .03 mg for an average of 5 months. Withdrawal bleeding lasted longer, 5.2-5.3 days (mean) than with conventional pills, 4.6 days. Nausea occurred less frequently, 8.5% in the 1st cycle compared with 25%. Loss of libido was reported about as often as with sequential pills. Breakthrough bleeding at intervals of 21 days or less happened in 225 wi th chlormadinone, 28% with norgestrel, and 8% with megestrol. Spotting was reported in 27% of the cycles on megestrol, 18% on chlormadinone, and 14.5% on norgestrel. The time interval from 1 withdrawal bleeding to the next averaged 29.1 days with megestrol, 25.6 days with chlormadinone, and 24.5 days with norgestrel. The variance of this interval was comparable to the 3 progestagens, but about half as large in Finnish women as in Swiss, indicating that the dose used was too high in the Swiss population.