Influence of the very low dose oral contraception on the blood presure, body weight and general condition of the patients
Nikolov, A.
Akusherstvo i Ginekologiia 48(4): 11-16
2009
ISSN/ISBN: 0324-0959 PMID: 20198780 Document Number: 209898
The aim of the study is to follow the influence of the very low dose oral contraception on the blood presure, body weight and general condition of the patients. 302 women at a mean age of 25.65 +/- 6.81 years were enroled in the study. They were treated with Lindynette-20 (20 mcg ethinyl-estradiol and 75 mcg gestodene) for six months. The mean systolic and diastolic blood pressure of the patients is as follows: at inclusion--Systolic 106.62 mmHg/Diastolic 67.88 mmHg, at the 3-th month--Systolic 106.84 mmHg/Diastolic 68.00 mmHg and at the 6-th month--Systolic 106.40 mmHg / Diastolic 68.51 mmHg. No statistically significant difference was found (p > 0.05). At the end of the sixth month 89.04% of the patients did not increased their body weight with more than 2 kg, in 6.31% it was reduced with more than 2 kg and in 4.65% was increased with more than 2 kg. The most frequent side effects were: headache (14%), breast tenderness (7%), nausea (3%), emotional instability (6%). At the end of the period most of the patients have excellent--81.13%, very good--17.55% and good--0.99% tolerance to the treatment. Use of a very low dose oral contraception does not lead to a significant changes in the blood pressure and clinically significant changes in the body weight with an excellent and very good treatment tolerance of the patients.