Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effect of epirubicin on 3H-thymidine labelling index in cultured L-strain cells

Ozcan, F.G.; Topçul, M.R.; Yilmazer, N.; Ridvanogullari, M.

Journal of Experimental and Clinical Cancer Research Cr 16(1): 23-27

1997

ISSN/ISBN: 0392-9078
PMID: 9148856
Document Number: 479404
The effect of epirubicin (EPI) on 3H-thymidine labelling index (3H-TdR LI) of L-strain cells in culture was investigated. EPI concentrations of 0.001 microg/ml, 0.01 microg/ml and 0.1 microg/ml were applied to the cells for 4, 8, 16 and 32 hours. Following the treatment with EPI, labelling process in 3H-TdR medium continued for 0, 2, 4, 8, 16, 20, 22, 25 and 30 hours. The results showed that EPI diminished labelling index of L-strain cells depends on time and applied concentrations. When compared to control this decrease was found statistically significant (p<0.001) in each group.

Document emailed within 1 workday
Secure & encrypted payments

Maksimova, G.F. 1972: Comparative analysis of the intensity of H3-thymidine labelling of spleen lymphoid cells in intact and immunized mice Biulleten' Eksperimental'noi Biologii i Meditsiny 73(3): 65-67
Zaslavsky, V.; Yakobson, E. 1975: Control of thymidine kinase synthesis in the cells infected with IHD strain of vaccinia virus Israel Journal of Medical Sciences 11(11): 1210
Ochi, T.; Takahashi, K.; Ohsawa, M. 1983: A mechanism for the stimulation by inorganic mercury of [3H] thymidine incorporation into DNA in cultured Molt-4F cells Japanese Journal of Experimental Medicine 53(4): 187-194
Sasaguri, Y.; Morimatsu, M.; Nakashima, T.; Tokunaga, O.; Yagi, K. 1985: Difference in the inhibitory effect of linoleic acid hydroperoxide on prostacyclin biosynthesis between cultured endothelial cells from human umbilical cord vein and cultured smooth muscle cells from rabbit aorta Biochemistry International 11(4): 517-521
Bottini, A.; Berruti, A.; Bersiga, A.; Brunelli, A.; Brizzi, M.P.; Marco, B.D.; Cirillo, F.; Bolsi, G.; Bertoli, G.; Alquati, P.; Dogliotti, L. 1996: Effect of neoadjuvant chemotherapy on Ki67 labelling index, c-erbB-2 expression and steroid hormone receptor status in human breast tumours Anticancer Research 16(5b): 3105-3110
Matturri, L.; Biondo, B.; Lavezzi, A.M. 1997: Thymidine labeling index in colorectal carcinoma: relation to clinicopathological parameters and to mitotic index Cancer Detection and Prevention 21(5): 471-475
Chen, M.; Li, L.; Deng, L.; Huang, H.; Lai, S. 2003: A system applying cyclic biaxial mechanical strain to cultured cells Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 20(3): 430-433
Kinahan, J.J.; Otten, M.; Grindey, G.B. 1979: Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine Cancer Research 39(9): 3531-3539
Smith, P.G.; Roy, C.; Dreger, J.; Brozovich, F. 1999: Mechanical strain increases velocity and extent of shortening in cultured airway smooth muscle cells American Journal of Physiology 277(2): L343-L348
Smith, P.G.; Tokui, T.; Ikebe, M. 1995: Mechanical strain increases contractile enzyme activity in cultured airway smooth muscle cells American Journal of Physiology 268(6 Pt 1): L999-1005
Chello, P.L.; McQueen, C.A.; DeAngelis, L.M.; Bertino, J.R. 1977: Comparative effects of folate antagonists versus enzymatic folate depletion on folate and thymidine enzymes in cultured mammalian cells Cancer Treatment Reports 61(4): 539-548
Gavignet, C.; Groult, N.; Godeau, G.; Robert, L.; Robert, A.M. 1989: Effect of procyanidolic oligomers on cultured mesenchymal cells. I. Effect on attachment, proliferation and detachment of cells Pathologie-Biologie 37(6): 746-753
Wygoda, M.R.; Wilson, M.R.; Davis, M.A.; Trosko, J.E.; Rehemtulla, A.; Lawrence, T.S. 1997: Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect Cancer Research 57(9): 1699-1703
Giannotti, V.; Pimpinelli, N.; Mariotti, V.; Borgognoni, L.; Reali, U.M. 1990: Cultured epidermis in the treatment of leg ulcer: "edge effect" and correlation with keratinocyte proliferation index Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale Societa Italiana di Dermatologia e Sifilografia 125(4): 161-167
Smart, I.H.; Smart, M. 1977: The location of nuclei of different labelling intensities in autoradiographs of the anterior forebrain of postnatial mice injected with [3H]thymidine on the eleventh and twelfth days post-conception Journal of Anatomy 123(Pt 2): 515-525
Sobel, R.A.; Colvin, R.B. 1985: The immunopathology of experimental allergic encephalomyelitis (EAE). III. Differential in situ expression of strain 13 Ia on endothelial and inflammatory cells of (strain 2 x strain 13)F1 guinea pigs with EAE Journal of Immunology 134(4): 2333-2337
Taylor, A.; Jones, O.W.; Grishaver, M.A. 1981: Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro Cancer Research 41(1): 192-196
Neustroev, G.V.; Petrov, K.I. 1978: Effect of an erythrocyte inhibitor on the in vitro incorporation of thymidine into the DNA of bone marrow cells Tsitologiia 20(2): 179-183
Simpson-Herren, L.; Sanford, A.H.; Holmquist, J.P.; Springer, T.A.; Lloyd, H.H. 1976: Ambiguity of the thymidine index Cancer Research 36(12): 4705-4709
Yoo, T.J.; Kuo, C.Y.; Spector, A.A.; Denning, G.M.; Floyd, R.; Whiteaker, S.; Kim, H.; Kim, J.; Abbas, M.; Budd, T.W. 1982: Effect of fatty acid modification of cultured hepatoma cells on susceptibility to natural killer cells Cancer Research 42(9): 3596-3600