Various aspects of increased resistance of the brain tissue and its vessels to extreme effects with the use of GABAergic compounds and Ca (2+) antagonists
Akopian, V.P.; Melkonian, K.V.; Samvelian, V.M.; Shirinian, E.A.; Mirzoian, N.R.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(5): 31-34
1997
ISSN/ISBN: 0869-2092 PMID: 9483402 Document Number: 479256
Experiments on rats showed that the morpho-functional state of the cerebral cortex microcirculatory bed suffers marked changes in different periods of hypokinesia. This was accompanied with obvious morphological changes in the brain, the development of brain edema in particular. It was found that the GABAergic agents which we used ranked below Ca-antagonists in antiedemic activity.