Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation
Riley, J.L.; Carroll, R.G.; Levine, B.L.; Bernstein, W.; St Louis, D.C.; Weislow, O.S.; June, C.H.
Journal of Immunology 158(11): 5545-5553
1997
ISSN/ISBN: 0022-1767 PMID: 9164979 Document Number: 479249
Two distinct mechanisms that account for the CD28 antiviral effect were identified: a trans effect , whereby CD28 induces enhanced secretion by CD4 and CD8 cells of antiviral soluble factors, including C-C chemokines; and a cis effect, whereby CD28 stimulation induces an intrinsic state of resistance of CD4 cells to infection with HIV-1. The trans effect is not specific for CD28, as other costimulatory receptors can substitute. In contrast, the cis effect appears to be specific to CD28 ligation.
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