A case of amiodarone and neuromyopathy
Silva Oropeza, E.; Peralta Rosado, H.R.; Valero Elizondo, C.; Sadowinski, E.; Magaña Serrano, J.A.
Revista de Investigacion Clinica; Organo del Hospital de Enfermedades de la Nutricion 49(2): 135-139
1997
ISSN/ISBN: 0034-8376 PMID: 9294958 Document Number: 478161
Amiodarone is a drug broadly used on cardiac arrhythmias despite its multiple side-effects. We present the case of an adult male with symptomatic ventricular tachycardia, receiving longterm amiodarone, who showed increased CK serum levels, sensorimotor neuropathy and secondary myopathy. Quadriceps biopsy showed atrophic changes and sural nerve intralysosomal deposits with intense axonal degeneration. The case illustrates the need to investigate and monitor peripheral neuropathy and muscular atrophy in chronic amiodarone use.