Deletion of MTS1/p16 gene in endometrial carcinoma
Zhou, C.; Sun, J.; Lu, S.
Zhonghua Zhong Liu Za Zhi 19(6): 404-406
1997
ISSN/ISBN: 0253-3766 PMID: 10920867 Document Number: 476909
To investigate the possible relationship between deletion of MTS1/p16 gene and progression of endometrial carcinoma. Thirty two primary endometrial carcinoma, 7 tumor-adjacent endometrial tissue and 10 normal endometrial tissue specimens were examined for homozygous deletion of MTS1/p16 gene by polymerase chain reaction-based analysis. Of 32 endometrial cancer specimens, 6(18.8%) showed homozygous deletion of MTS1/p16 gene. No deletion was detected in the tumor-adjacent and normal endometrial tussues. Nor was it detected in well differentiated endometrial carcinoma. Deletion of MTS1/p16 gene might contribute to the progression of endometrial carcinoma and could be served as indicator for predicting prognosis.