Cyclosporine: update on pharmacology, analytical techniques and therapeutic monitoring
Santori, L.; Rastelli, M.; Arena, B.; Morleo, M.A.
Bollettino Chimico Farmaceutico 136(9): 577-588
1997
ISSN/ISBN: 0006-6648 PMID: 9440351 Document Number: 476018
The Authors relate about the current state of knowledge on Cyclosporin A metabolism, mechanism of action, toxic potential, necessity of therapeutic monitoring. The methods for measurement of Cyclosporin A and its metabolites and the study of their immunosuppressive activity are described. Their use for measurement of Cyclosporin G is discussed.