Malignant lymphoma of the transverse colon associated with macroglobulinemia
Yasui, O.; Tukamoto, F.; Sasaki, N.; Saito, T.; Yagisawa, H.; Uno, A.; Nanjo, H.
American Journal of Gastroenterology 92(12): 2299-2301
1997
ISSN/ISBN: 0002-9270 PMID: 9399775 Document Number: 475972
We present an unusual case of a malignant lymphoma of the transverse colon associated with macroglobulinemia. A 73-yr-old man was incidentally discovered to have high serum gamma-globulin on a regular check-up. Serum immunoquantitation revealed an IgM level of 3490 mg/dl. Kappa-type Bence-Jones protein was positive in the urine. Immunoelectrophoresis identified the abnormal protein as IgM-kappa. After hospitalization an abdominal tumor was detected with barium and CT, identified as a tumor of the transverse colon. Partial resection of the transverse colon was carried out. Histopathologically the tumor were confirmed as small lymphocytic non-Hodgkin lymphoma of B-cell origin, based on the Working Formulation. According to flowcytometric analysis, the tumor cells were positive for IgM-kappa. The lymphoma cells produced monoclonal IgM, giving rise to macroglobulinemia.