Ki-67, ploidy and S-phase fraction as prognostic factors in gastric cancer
Victorzon, M.; Roberts, P.J.; Haglund, C.; von Boguslawsky, K.; Nordling, S.
Anticancer Research 17(4b): 2923-2926
1997
ISSN/ISBN: 0250-7005 PMID: 9329565 Document Number: 475397
The prognostic value of the immunohistochemical expression of Ki-67 in paraffin embedded specimens was studied in 242 patients with gastric adenocarcinoma. The results were compared with ploidy and S-phase fraction (SPF) obtained by DNA flow cytometry. Both SPF and ploidy correlated with survival in univariate analysis. In multivariate survival analysis, stage of disease, DNA ploidy and presence of distant metastases emerged as independent prognostic parameters. There was no significant difference in survival between patients having tumours with high and low Ki-67 labelling, neither in univariate- nor in multivariate survival analysis.