Infants of diabetic mothers (IDM) . i -- Macrosomia and growth factors
Martín Carballo, G.; Fernández Cano, G.; Grande Aragón, C.; Méndez Alavedra, J.; Hawkins Carranza, F.; Gracia Bouthelier, R.
Anales Espanoles de Pediatria 47(3): 295-301
1997
ISSN/ISBN: 0302-4342 PMID: 9499284 Document Number: 474539
The objective of this study was to determine the incidence of macrosomia in infants of diabetic mothers (IDM) and to analyze its possible correlation with insulin, C-peptide, growth hormone (GH) and IGF-I levels in umbilical cord blood. A prospective study of 58 IDM and 58 control newborns (33 males and 25 females in both groups) was carried out. The incidence of macrosomia was 25.8% in the IDM group and 61.5% in the IIDDM group (infant of insulin-dependent diabetic mother) compared to 5% in the control group. There was a positive correlation between maternal Hgb Alc levels in the third trimester of gestation and insulin and C-peptide levels with newborn weight in the IDM group (especially in the IIDDM group). IGF-I levels were positively correlated with newborn weight in both control and IDM groups. There was no correlation between GH and IGF-I levels in any group.