Cytogenetic effects of the herbicide chloridazon in cultured sheep lymphocytes
Siviková, K.; Dianovský, J.
Acta Veterinaria Hungarica 45(1): 11-16
1997
ISSN/ISBN: 0236-6290 PMID: 9270125 Document Number: 473234
The effect of in vitro exposure to the herbicide chloridazon on the induction of chromosome aberrations (CA) and sister chromatid exchanges (SCE) was studied in cultured sheep peripheral lymphocytes. A positive clastogenic effect was observed in chloridazon-treated cultures at a dose of 7 x 10-4M both in the presence and absence of the S9 fraction, but no significant increase of chromosome breaks was seen at lower doses (7 x 10-6M and 7 x 10-5M, respectively). There were clear dose-dependent and significant differences in chloridazon potency to induce SCEs. Induction of cell cycle delays as compared with the controls was not observed.