Amanita poisoning and the importance of sorption hemoperfusion in its therapy
Monhart, V.
Vnitrni Lekarstvi 43(10): 686-690
1997
ISSN/ISBN: 0042-773X PMID: 9601885 Document Number: 473051
Intoxications with poisonous mushrooms, in particular toadstools, are still a serious medical problem. The author presents contemporary views on the etiopathogenesis of intoxications with Amanita phalloides, the clinical picture of the phalloid syndrome and its prognosis. He emphasizes the importance of a comprehensive therapeutic approach, incl. the administration of antidotes (penicillin G and silibinin) and extracorporeal haemoelimination treatment. Early sorption haemoperfusion, either alone or combined with haemodialysis or plasmapheresis, prevent the development of hepatic and renal failure and significantly reduce the mortality from mushroom poisoning. The results of amanitine sorption in in vitro experiments and in the treatment of human intoxications justify the use of biocompatible synthetic resin sorbents (Amberlite XAD-2) in the treatment of mushroom poisoning rather than active charcoal.