Effect of zinc-metallothionein on DNA replicative synthesis and single-stranded DNA-binding protein (SSB-protein) content in chromatin of mice bone marrow cells
Koterov, A.N.
Ukrainskii Biokhimicheskii Zhurnal 69(1): 84-87
1997
ISSN/ISBN: 0201-8470 PMID: 9454385 Document Number: 472885
It was shown that the incubation in vitro of mice bone marrow cells with rat hepatic zinc-metallothionein (10-138 micrograms per 10(7) nuclear cells) leads to simultaneous 1.2-1.4 fold increase of DNA replicative synthesis level and 1.2-3 fold increase of the content of single-stranded DNA-binding proteins in chromatin of nuclear cells. Possible mechanisms of these effects connected with zinc ions donation and the increase of the content of DNA with single-stranded regions were discussed.