Adoptive transfer of immunity induced with chloroquine attenuated Plasmodium yoelii nigeriensis from immune to immunologically naive mice
Kimbi, H.K.; Fagbenro-Beyioku, A.F.
West African Journal of Medicine 16(1): 44-47
1997
ISSN/ISBN: 0189-160X PMID: 9133824 Document Number: 471875
Immunity was induced in albino mice using chloroquine-attenuated Plasmodium yoelii nigeriensis which had been maintained under drug pressure in 4 passages. Attempts were made to adoptively transfer immunity from the immune to immunologically naive mice by means of serum, spleen and thoracic duct extracts. None of them conferred complete immunity on the recipients but some protection was gained. This was evident from the prolongation of both the prepatent period and the survival period of the host mice. The best protection conferred by the different extracts was seen in groups that received 0.4 ml serum, 0.9 ml spleen and 1.2 ml thoracic duct extracts, whose survival periods lasted 23, 21 and 15 days, respectively, compared to 9 days for the controls.