Purinoceptor-induced cytoplasmic calcium oscillation in megakaryocytes
Uneyama, C.
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo Hokoku 115: 49-71
1997
ISSN/ISBN: 1343-4292 PMID: 9641818 Document Number: 471271
Megakaryocytes isolated from rat bone marrow respond to externally applied ATP and ADP, showing a periodic K+ current that reflects oscillation in cytoplasmic calcium concentration. The agonist selectivity of the purinoceptor on the megakaryocyte is unique. In addition, the intracellular mechanism of calcium oscillation and the effects of many modulating factors were investigated.
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