The epidural use of morphine and alpha 2-agonists for postoperative analgesia
Dobrydnev, I.; Samariutel', I.
Anesteziologiia i Reanimatologiia 4: 7-11
1997
ISSN/ISBN: 0201-7563 PMID: 9382235 Document Number: 471068
Three protocols of postoperative pain relief after gastric surgery were used in 60 male patients: regular intramuscular morphine, epidural morphine, and epidural morphine with 0.1 mg of clonidine. Pain relief was more effective with the epidural route of administration. Addition of clonidine in a daily dose of 0.1 mg allowed a twofold decrease of epidural morphine dose, involving lesser hyperdynamic postoperative cardiovascular changes and complete elimination of psychotic complications and delirium in alcohol-dependent patients.