The pharmacokinetics of Kefzol in patients with acute pancreatitis when administered intravenously and endolymphatically
Pugaev, A.V.; Bogomolova, N.S.; Bagdasarov, V.V.; Sirozhitdinov, K.B.; Vinogradova, L.N.
Likars'ka Sprava 3: 123-125
1997
ISSN/ISBN: 1019-5297 PMID: 9377331 Document Number: 471036
Pharmacokinetics was studied of kefsole administered by intravenous and endolymphatic routes to patients (n = 23) with acute pancreatitis. The studies made showed that intravenous route for the drug administration makes for a quicker entering of the antibiotic into the peritoneal exudate. Apart from these reasons, endolymphatic antibacterial therapy does not appear to avert the development of complications involving pus-formation/discharging in acute pancreatitis and does not seem to be essential in the complex of therapeutic measures to be applied for treating the above patients.