Radiation induced adaptation in peripheral blood reticulocytes of mice
Lenarczyk, M.; Słowikowska, M.G.; Majle, T.
Roczniki Panstwowego Zakladu Higieny 48(3): 239-244
1997
ISSN/ISBN: 0035-7715 PMID: 9432700 Document Number: 470755
An in vivo micronucleus assay in mice reticulocytes of peripheral blood for identifying the possibility of induction of adaptive response to various doses of radiation: 2.5 cGy or 5.0 cGy as adapting and 50 cGy or 100 cGy as challenging doses was performed. The most effective inhibition of frequency appearance of micronucleus in RETs of mice (i.e. adaptive response) takes place et the following experimental conditions: 5.0 cGy as adaptive dose and 50 cGy challenging dose. The interval between them were 4 hours. The maximum inhibition of frequency of micronucleus was et 24 h sampling time after exposure of challenging dose. This reduction was statistically significant (p < 0.05; p < 0.01-chi square test).