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Alteration of p15 and p16 gene in gastric cancer

Fushida, S.; Yonemura, Y.; Kawamura, T.; Nojima, N.; Satoh, T.; Fujita, H.; Michiwa, Y.; Fujimura, T.; Nishimura, G.; Miwa, K.; Miyazaki, I.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 24(Suppl 2): 279-284

1997

ISSN/ISBN: 0385-0684
PMID: 9263516
Document Number: 470518
We analyzed p15 and p16 gene alterations in gastric cancer. Only MKN45 showed both homozygous deletions but other cell lines and all of tumor specimens did not show any alterations. Using RT-PCR analysis, decreased or no expression of the p16 gene was found in 1 of 7 cell lines (except MKN45) (14.2%) and in 8 of 20 tumors (40%), whereas no abnormalities of p15 gene expression were found. These results suggest that the p16 gene may correlate with tumorigenesis and tumor expansion due to decrease or loss of gene products in gastric cancer.

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Wang, B.; Li, L.; Yao, L.; Liu, L.; Zhu, Y. 2001: Detection of p53 gene alteration in sputum sample and its implications in early diagnosis of lung cancer Zhonghua Nei Ke Za Zhi 40(2): 101-104
Matsukura, N.; Onda, M.; Okino, T.; Shimada, T. 2001: Gastric cancer--novel strategy of gene therapy for gastric cancer Nihon Rinsho. Japanese Journal of Clinical Medicine 59(1): 90-93
Yamada, Y.; Yoshida, T.; Hayashi, K.; Sekiya, T.; Yokota, J.; Hirohashi, S.; Nakatani, K.; Nakano, H.; Sugimura, T.; Terada, M. 1991: p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases Cancer Research 51(21): 5800-5805
Somasundaram, K.; Ganguly, A.K. 1985: Gastric mucosal protection during restraint stress in rats: alteration in gastric adherent mucus and dissolved mucus in gastric secretion Hepato-Gastroenterology 32(1): 24-26
Qin, X.-y.; Liu, F.-l. 2007: Progression of gene research in gastric cancer Zhonghua Wei Chang Wai Ke Za Zhi 10(5): 407-409
Matsukura, N.; Onda, M.; Hasegawa, H.; Tokunaga, A.; Hoshino, A.; Igarashi, T.; Suzuki, S.; Shimada, T. 1997: Prospect of gene therapy for metastatic foci of gastric cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 24(12): 1778-1780
Du, J.-j.; Dou, K.-f.; Peng, S.-y.; Wang, Z.-h.; Chu, G.-h.; Wang, W.-z.; Gao, Z.-q. 2007: Isolation of a down-regulated novel gene with lower abundance in gastric cancer Zhonghua Wei Chang Wai Ke Za Zhi 10(2): 173-176
Jiang, Z.; Zhang, Z.; Wang, Z.; Zhang, G.; Hu, K.; He, B.; Wang, S. 2012: Association of the 463G-A myeloperoxidase gene polymorphism with gastric cancer risk Hepato-Gastroenterology 59(115): 757-761
Bobarykina, A.Y.; Minchenko, D.O.; Opentanova, I.L.; Moenner, M.; Caro, J.; Esumi, H.; Minchenko, O.H. 2006: Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers Acta Biochimica Polonica 53(4): 789-799
Lan, B.; Liu, B.-y.; Zhang, J.; Wang, K.-k.; Chen, X.-h.; Zhu, Z.-g. 2005: Analysis of gene expression profile of G1/S transition in gastric cancer cell cycle Zhonghua Wei Chang Wai Ke Za Zhi 8(3): 229-233
Si, P.-r.; Fang, D.-c.; Zhang, H.; Yang, L.-q.; Luo, Y.-h.; Liao, H.-y. 2005: The relationship between methylenetetrahydrofolate reductase gene polymorphism and microsatellite instability in gastric cancer Zhonghua Liu Xing Bing Xue Za Zhi 26(10): 794-799
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Fan, L.-q.; Li, Y.; Zhao, Q.; Tan, B.-b.; Ma, L.-g.; Liu, Y.; Wang, D. 2014: Comparative proteomics in gastric cancer cell line BGC823 after ZNF139 gene inhibited with RNA interference Hepato-Gastroenterology 61(134): 1822-1829
Ishida, Y.; Kawakami, K.; Tanaka, Y.; Kanehira, E.; Omura, K.; Watanabe, G. 2002: Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer Anticancer Research 22(5): 2805-2809
Luo, J.; Wang, X.-b.; Yu, Q.-m.; Zhao, T.; Fang, R.-g.; Wang, J.-j.; Zheng, Z.-g.; Yu, J.-l.; Fang, X.-h.; Wang, S.; Ling, Z.-q. 2012: Methylation status of CDH1 gene in preoperative abdominal lavage of patients with gastric cancer and its clinical significance Zhonghua Wei Chang Wai Ke Za Zhi 15(7): 710-714
Zhao, G.-q.; Wang, L.; Dong, Z.-m. 2008: Preliminary study of DNA polymerase beta gene silencing by small interfering RNA in human gastric cancer BGC-823 cells Zhonghua Zhong Liu Za Zhi 30(10): 729-732
Quackenbush, L.J.; Gorzynski, T.J.; Dowjat, W.K.; Zaleski, M.B. 1987: Effect of alteration of murine Ir-Thy-1 gene product on anti-Thy-1 response Transplantation Proceedings 19(1 Pt 1): 880-882
Wu, B.-w.; Zhang, J.; Fei, X.-f.; Zhu, Z.-g.; Cao, W.-x. 2007: Reappraisal of the impacts of human Runt-related transcription factor gene 3 expression on differentiation and prognosis of gastric cancer Zhonghua Wei Chang Wai Ke Za Zhi 10(2): 165-168
Sugano, K. 2015: Upper G.I. Cancer. III. Gastric Cancer Prevention of Gastric Cancer by Eradication of Helicobacter pylori Gan to Kagaku Ryoho. Cancer and ChemoTherapy 42(9): 1059-1063
Sato, Y.; Ishii, H.; Terada, T.; Amaya, S.; Koizumi, H.; Fujisawa, K.; Munemoto, Y.; Mitsui, T.; Iida, Y.; Miura, S. 2010: A case of AFP-producing gastric cancer with hepatic metastases that accompanied early gastric cancer treated effectively by chemotherapy Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(10): 1957-1960