The role of Na,K-ATPase inhibitors in hypertension and end-stage renal disease
Bargman, J.M.
Peritoneal Dialysis International Journal of the International Society for Peritoneal Dialysis 17(6): 536-540
1997
ISSN/ISBN: 0896-8608 PMID: 9655151 Document Number: 469724
To review the role of Na,K-ATPase inhibitors in the pathogenesis of essential hypertension and hypertension associated with end-stage renal disease. MEDLINE search, 1966 to 1997. There is a suggestive physiologic and epidemiologic relationship between Na,K-ATPase inhibition and hypertension. However, clearance data cannot support the hypothesis that differential metabolism of this family of compounds explains the improved hypertensive control seen in patients on peritoneal dialysis compared to those on hemodialysis. As a result of the complex methodologies involved, it is unclear whether Na,K-ATPase inhibitors play a significant role in the hypertension of end-stage renal disease in general and peritoneal dialysis in particular.