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The effect of acute and chronic cadmium and gamma radiation exposures on micronucleus formation in mouse bone marrow cells

Privezentsev, K.V.

Tsitologiia i Genetika 31(1): 11-16

1997

ISSN/ISBN: 0564-3783
PMID: 9381550
Document Number: 469655
It was shown using micronucleus test that Cd chloride in drinking water (5 mg Cd2+/1, 32 days) does not induce cytogenetic damages in mouse bone marrow cells and does not affect the yield of micronuclei (MN) after chronic gamma-irradiation (1 Gy), whereas Cd chloride injection (1 mg Cd2+/kg body wt) leads to an increase in the number of MN. At the same time, both acute and chronic Cd2+ treatment decrease the number of MN induced by acute irradiation. The protective effect of Cd2+ is supposed to be due to activation of repair processes or metallothionein induction.

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