Molecular biology markers of neuroblastoma as the basis for a therapy concept
Girgert, R.; Treuner, J.; Schweizer, P.
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 113: 1053-1055
1996
ISSN/ISBN: 0942-2854 PMID: 9101780 Document Number: 468814
Molecular biological markers that influence prognosis should be considered in the optimization of therapy for disseminated forms of neuroblastoma. Some of these markers include: N-myc amplification, deletion of 1p36, ploidy, and trk expression. Neuroblastoma without N-myc amplification and high trk expression show a favorable outcome and would enable a more gentle chemotherapy treatment. Neuroblastomas with N-myc amplification and lack of trk expression behave extremely unfavorably and require an even more intensive treatment.