Cancer and Leukemia Group B trials for advanced prostate cancer
Small, E.J.; Dawson, N.A.; Kantoff, P.W.; Vogelzang, N.J.
Seminars in Oncology 23(6 Suppl 14: 28-31
1996
ISSN/ISBN: 0093-7754 PMID: 8996582 Document Number: 468373
The approach to treatment for advanced prostate cancer patients who have failed to respond to therapy with androgen deprivation has undergone a significant and fundamental transformation over the last 3 years, beginning with the description of the flutamide-withdrawal syndrome in 1993. This was the same year that the Cancer and Leukemia Group B Prostate Cancer Committee was created. This committee has been studying the following two important areas in advanced prostate cancer the optimal treatment and biology of androgen-independent, yet hormonally sensitive, prostate cancer; and the optimal treatment for patients with truly hormone-refractory disease. Important biologic and quality of life correlative trials will complement the clinical information gained, with the goal of providing further insight into the extremely complex biological processes involved.