Two cases of relapse or refractory germ cell tumor who had been treated with combination chemotherapy of cisplatin and carboplatin
Kiyama, Y.; Suzuki, G.; Masauzi, N.; Ohizumi, H.; Kobayashi, N.; Ogasawara, M.; Naohara, T.; Saito, M.; Higa, T.; Kasai, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 23(14): 1989-1992
1996
ISSN/ISBN: 0385-0684 PMID: 8978809 Document Number: 468211
We tried a combination chemotherapy with cisplatin (CDDP) and carboplatin (CBDCA) (CDDP/CBDCA regimen) as salvage therapy for 2 cases with recurrent or refractory Germ Cell Tumor (GCT). Case 1 was a 29-year-old man with 2nd relapsed embryonal carcinoma and seminoma originating from testis. Case 2 was a 23-year-old man with primary refractory embryonal carcinoma and yolk sac tumor originating from mediastinum. CDDP and CBDCA were administered at the dose of 120 mg/m2 and 350 mg/m2 on day 1, and vinblastin was administered at the dose of 10 mg/body on day 2. In one of two cases, a complete response was obtained. Non-hematologic toxicity of CDDP/CBDCA regimen was tolerable. It is suggested that this combination chemotherapy is useful for GCT recurrence.