Abnormalitis in the distributions of ventilation-perfusion ratios and diffusing capacity-perfusion ratios in three types of chronic obstructive pulmonary disease
Yamaguchi, K.; Mori, M.; Kawai, A.; Takasugi, T.; Koda, E.; Aoki, T.; Suzuki, K.; Miyata, T.; Nishio, K.; Suzuki, Y.
Nihon Kyobu Shikkan Gakkai Zasshi 34(8): 856-863
1996
ISSN/ISBN: 0301-1542 PMID: 8965394 Document Number: 468075
To assess whether diffusion-limited gas exchange plays a significant role in hypoxemia in various types of chronic obstructive pulmonary disease(COPD), we analyzed the distribution of ventilation-perfusion (VA/Q) ratios and of diffusing capacity-perfusion (G/Q) ratios. We compared VA/Q and G/Q distribution in patients with three basic types of COPD: emphysematous changes, bronchiolar involvement, and airway hypersecretion, which were classified based on symptoms and on findings of high-resolution CT. The results were that 1) hypoxemia was not caused by diffusion-limited gas exchange with low G/Q regions in any type of COPD, that 2) hypoxemia was not caused by inhomogeneities in VA/Q distribution, that 3) emphysematous changes and bronchiolar involvement were associated with high and low VA/Q regions, respectively, and that 4) either hypersecretion itself or related airway abnormalities may cause low VA/Q regions to form.