Monoclonal antibodies and transplantation
Hourmant, M.
Nephrologie 17(8): 435-440
1996
ISSN/ISBN: 0250-4960 PMID: 9036366 Document Number: 467805
Several monoclonal antibodies have been evaluated in allograft transplantation, these past years, without being able, to date, to replace polyclonal antibodies. They are classified in four families, each having an individual interest: antibody directed against the CD3/T receptor complex; anti-interleukine II receptor antibodies, specifically blocking activated T lymphocytes; antibodies against adhesion molecules, mainly LFA1 and ICAM1, that, by preventing the reperfusion injury syndrome, should have many clinical applications in the future; antibodies against co-receptor molecules, such as CD4, inducing indefinite allograft tolerance in models of transplantation in rodents, that could be reproducible in human.