A patient with Creutzfeldt-Jakob disease following treatment with human growth hormone
Roos, R.A.; Wintzen, A.R.; Will, R.G.; Ironside, J.W.; van Duinen, S.G.
Nederlands Tijdschrift Voor Geneeskunde 140(22): 1190-1193
1996
ISSN/ISBN: 0028-2162 PMID: 8692356 Document Number: 467131
In a 39-year old woman Creutzfeldt-Jakob disease was diagnosed. More than twenty years prior to the first clinical symptoms she had been treated with human pituitary growth hormone. After four months of illness she died of Creutzfeldt-Jakob disease, as was shown by the post-mortem finding of spongiform encephalopathy immunochemically positive for abnormal prion protein. The patient represented the first case of Creutzfeldt-Jakob disease associated with the use of human growth hormone in the Netherlands.