Simple method for detection of MYH11 DNA rearrangements in patients with inv(16)(p13q22) and acute myeloid leukemia

van der Reijden, B.A.; Martinet, D.; Dauwerse, J.G.; Giles, R.H.; Wessels, J.W.; Beverstock, G.C.; Smit, B.; Mühlematter, D.; Jotterand Bellomo, M.; Gabert, J.; Lafage-Pochitaloff, M.; Reiffers, J.; Bilhou-Nabera, C.; van Ommen, G.J.; Hagemeijer, A.; Breuning, M.H.; van der Reijden, B.A; Martinet, D; Dauwerse, J.G; Giles, R.H; Wessels, J.W; Beverstock, G.C; Smit, B; Mühlematter, D; Jotterand Bellomo, M; Gabert, J; Lafage-Pochitaloff, M; Reiffers, J; Bilhou-Nabera, C; van Ommen, G.J; Hagemeijer, A; Breuning, M.H

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Simple method for detection of MYH11 DNA rearrangements in patients with inv (16) (p13q22) and acute myeloid leukemia

van der Reijden, B.A.; Martinet, D.; Dauwerse, J.G.; Giles, R.H.; Wessels, J.W.; Beverstock, G.C.; Smit, B.; Mühlematter, D.; Jotterand Bellomo, M.; Gabert, J.; Lafage-Pochitaloff, M.; Reiffers, J.; Bilhou-Nabera, C.; van Ommen, G.J.; Hagemeijer, A.; Breuning, M.H.

Leukemia 10(9): 1459-1462

1996

ISSN/ISBN: 0887-6924

PMID: 8751463

Document Number: 466647

The pericentric inversion on chromosome 16 (inv(16)(p13q22)) and related t(16;16)(p13;q22) are recurrent aberrations associated with acute myeloid leukemia (AML) M4 Eo. Both abberations result in a fusion of the core binding factor beta (CBFB) and smooth muscle myosin heavy chain gene (MYH11). A selected genomic 6.9-kb BamHI probe detects MYH11 DNA rearrangements in 18 of 19 inv(16)/t(16;16) patients tested using HindIII digested DNA. The rearranged fragments were not detectable after remission in two cases tested, while they were present after relapse in one of these two cases tested.