The biochemical and clinical aspects of the participation of granulocytes and their proteinases in a vascular wall lesion
Ogloblina, O.G.; Belova, L.A.; Arkhakova, I.A.; Domba, G.I.; Arabidze, G.G.; Kukharchuk, V.V.
Terapevticheskii Arkhiv 68(5): 78-80
1996
ISSN/ISBN: 0040-3660 PMID: 9082609 Document Number: 466342
Some components of plasma and granulocyte proteolytic system, granulocyte activation degree were evaluated in 15 patients with nonspecific aortic arteritis (NAA) and 12 hereditary hypercholesterolemia (HHC) patients. Catepsin G activity in blood plasma of NAA and HHC patients was higher than in donors 8-9 and 6-fold, respectively (p < 0.001). Granulocyte collagenase activity, spontaneous NBT test values in them were higher than in donors 6 and 4-fold (p < 0.02 and p < 0.01, respectively), 2-fold (p < 0.005 and p < 0.001, respectively). The data obtained confirm the suggestion on the presence of an inflammatory component not only in pathogenesis of NAA, but also in HHC causation.