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A method for selecting drugs that affect the rheological properties of the blood in vitro

Plotnikov, M.B.; Koltunov, A.A.; Aliev, O.I.

Eksperimental'naia i Klinicheskaia Farmakologiia 59(6): 54-55

1996

ISSN/ISBN: 0869-2092
PMID: 9181877
Document Number: 466209
For the selection of compounds affecting the hemorrheologic status a method for reproducing disorders of blood rheologic properties in vitro was developed. It consists in 60-min incubation of blood at 42 degrees C. The hemorrheologic effect of quercetin under such conditions was studied and a dependence of the effect of quercetin on blood viscosity and red cell aggregation on the drug concentration was revealed.

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