The effect of calcium antagonist on ischemia-reperfusion injury of the rabbit retina
Mori, T.; Sugawara, T.; Hosobe, Y.; Gotoh, T.; Kato, C.; Tazawa, Y.
Nippon Ganka Gakkai Zasshi 100(10): 773-776
1996
ISSN/ISBN: 0029-0203 PMID: 8937100 Document Number: 466003
We investigated the effect of nicardipine (NC), a calcium antagonist, on retinal ischemia-reperfusion injury. Electroretinogram (ERG) was recorded from rabbit eyes before and after ischemia produced by increasing intraocular pressure to 140 mmHg for 90 min after giving 0.01% NC (0.1 ml) intravitreally (n = 4). ERGs from intact (non-ischemic) rabbit eyes after injecting NC intravitreally was also recorded (n = 4) (NC group). The recovery rate of b-wave amplitude after reperfusion was significantly higher in the NC group than in the control group which was given saline without NC (p < 0.05). There were no significant differences between the NC and the control groups in a-wave amplitude and implicit time of the b-wave. No significant changes were detected in the a-wave or b-wave amplitude after intravitreal injection of NC into the intact eyes. We suggest that NC can prevent ischemia-reperfusion injury of the rabbit retina and could be considered for clinical use.